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Front cover: A functional pseudogene, NMRAL2P , is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane‐treated colon cancer cells
Author(s) -
Johnson Gavin S.,
Li Jia,
Beaver Laura M.,
Dashwood W. Mohaiza,
Sun Deqiang,
Rajendran Praveen,
Williams David E.,
Ho Emily,
Dashwood Roderick H.
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201770041
Subject(s) - pseudogene , sulforaphane , gene , front cover , coactivator , biology , genetics , homology (biology) , computational biology , cancer research , microbiology and biotechnology , genome , transcription factor , cover (algebra) , mechanical engineering , engineering
Mol. Nutr. Food Res . 2017, 61 , 1600769. DOI: 10.1002/mnfr.201600769 Pseudogenes have been viewed, historically, as nonfunctional DNA sequences with close homology to other functional protein‐coding genes. NmrA‐like redox sensor 2 ( NMRAL2P ) is a novel functional pseudogene, the first to be identified both as a direct transcriptional target of Nrf2, and as a downstream co‐regulator of Nrf2‐dependent gene activation in response to sulforaphane treatment.