Front cover: A functional pseudogene,  NMRAL2P , is regulated by Nrf2 and serves as a coactivator of  NQO1  in sulforaphane‐treated colon cancer cells | Zendy

Johnson Gavin S. | Zendy; Li Jia | Zendy; Beaver Laura M. | Zendy; Dashwood W. Mohaiza | Zendy; Sun Deqiang | Zendy; Rajendran Praveen | Zendy; Williams David E. | Zendy; Ho Emily | Zendy; Dashwood Roderick H. | Zendy

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Front cover: A functional pseudogene, NMRAL2P , is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane‐treated colon cancer cells

Author(s) -

Johnson Gavin S.,

Li Jia,

Beaver Laura M.,

Dashwood W. Mohaiza,

Sun Deqiang,

Rajendran Praveen,

Williams David E.,

Ho Emily,

Dashwood Roderick H.

Publication year - 2017

Publication title -

molecular nutrition and food research

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.495

H-Index - 131

eISSN - 1613-4133

pISSN - 1613-4125

DOI - 10.1002/mnfr.201770041

Subject(s) - pseudogene , sulforaphane , gene , front cover , coactivator , biology , genetics , homology (biology) , computational biology , cancer research , microbiology and biotechnology , genome , transcription factor , cover (algebra) , mechanical engineering , engineering

Mol. Nutr. Food Res . 2017, 61 , 1600769. DOI: 10.1002/mnfr.201600769 Pseudogenes have been viewed, historically, as nonfunctional DNA sequences with close homology to other functional protein‐coding genes. NmrA‐like redox sensor 2 ( NMRAL2P ) is a novel functional pseudogene, the first to be identified both as a direct transcriptional target of Nrf2, and as a downstream co‐regulator of Nrf2‐dependent gene activation in response to sulforaphane treatment.

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