Premium
Back cover: Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling
Author(s) -
Song Jiajia,
Wang Qian,
Du Min,
Li Tiange,
Chen Bin,
Mao Xueying
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201770024
Subject(s) - ampk , protein kinase b , insulin resistance , insulin receptor substrate , insulin receptor , phosphorylation , medicine , gluconeogenesis , chemistry , protein kinase a , amp activated protein kinase , insulin , endocrinology , glycogen , irs1 , biochemistry , biology , enzyme
Mol. Nutr. Food Res . 2017, 61 , 1600301. DOI: 10.1002/mnfr.201600301 The glycomacropeptide (GMP)‐derived peptide IPPKKNQDKTE activates the insulin receptor substrate (IRS)/protein kinase B (Akt) signaling pathway by increasing phosphorylation levels of AMP‐activated protein kinase (AMPK) in high‐glucose‐induced insulin resistant HepG2 cells. This ultimately modulates high‐glucose‐induced abnormal gluconeogenesis and glycogen synthesis.