Back cover: Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling | Zendy

Song Jiajia | Zendy; Wang Qian | Zendy; Du Min | Zendy; Li Tiange | Zendy; Chen Bin | Zendy; Mao Xueying | Zendy

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Back cover: Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling

Author(s) -

Song Jiajia,

Wang Qian,

Du Min,

Li Tiange,

Chen Bin,

Mao Xueying

Publication year - 2017

Publication title -

molecular nutrition and food research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.495

H-Index - 131

eISSN - 1613-4133

pISSN - 1613-4125

DOI - 10.1002/mnfr.201770024

Subject(s) - ampk , protein kinase b , insulin resistance , insulin receptor substrate , insulin receptor , phosphorylation , medicine , gluconeogenesis , chemistry , protein kinase a , amp activated protein kinase , insulin , endocrinology , glycogen , irs1 , biochemistry , biology , enzyme

Mol. Nutr. Food Res . 2017, 61 , 1600301. DOI: 10.1002/mnfr.201600301 The glycomacropeptide (GMP)‐derived peptide IPPKKNQDKTE activates the insulin receptor substrate (IRS)/protein kinase B (Akt) signaling pathway by increasing phosphorylation levels of AMP‐activated protein kinase (AMPK) in high‐glucose‐induced insulin resistant HepG2 cells. This ultimately modulates high‐glucose‐induced abnormal gluconeogenesis and glycogen synthesis.

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