Front cover: A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target‐gene expression | Zendy

Downing Laura E. | Zendy; Ferguson Bradley S. | Zendy; Rodriguez Kelvin | Zendy; Ricketts MarieLouise | Zendy

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Front cover: A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target‐gene expression

Author(s) -

Downing Laura E.,

Ferguson Bradley S.,

Rodriguez Kelvin,

Ricketts MarieLouise

Publication year - 2017

Publication title -

molecular nutrition and food research

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.495

H-Index - 131

eISSN - 1613-4133

pISSN - 1613-4125

DOI - 10.1002/mnfr.201770021

Subject(s) - histone deacetylase , chemistry , hdac1 , gene expression , phosphorylation , catabolism , histone , biochemistry , gene , microbiology and biotechnology , biology , metabolism

Mol. Nutr. Food Res . 2017, 61 , 1600347. DOI: 10.1002/mnfr.201600347 Grape seed procyanidin extract (GSPE) inhibits histone deacetylase (HDAC) 2 and 3. HDAC inhibition leads to increased PPARα target‐gene transcription enhancing fatty acid catabolism, correlating with reduced serum triglyceride levels. GSPE‐induced HDAC inhibition may represent a new mechanism underlying its hypotriglyceridemic action.

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