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Front cover: A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target‐gene expression
Author(s) -
Downing Laura E.,
Ferguson Bradley S.,
Rodriguez Kelvin,
Ricketts MarieLouise
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201770021
Subject(s) - histone deacetylase , chemistry , hdac1 , gene expression , phosphorylation , catabolism , histone , biochemistry , gene , microbiology and biotechnology , biology , metabolism
Mol. Nutr. Food Res . 2017, 61 , 1600347. DOI: 10.1002/mnfr.201600347 Grape seed procyanidin extract (GSPE) inhibits histone deacetylase (HDAC) 2 and 3. HDAC inhibition leads to increased PPARα target‐gene transcription enhancing fatty acid catabolism, correlating with reduced serum triglyceride levels. GSPE‐induced HDAC inhibition may represent a new mechanism underlying its hypotriglyceridemic action.