Premium
The Oral Bioavailability of Trans ‐Resveratrol from a Grapevine‐Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization
Author(s) -
CalvoCastro Laura A.,
Schiborr Christina,
David Franziska,
Ehrt Heidi,
Voggel Jenny,
Sus Nadine,
Behnam Dariush,
BosyWestphal Anja,
Frank Jan
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201701057
Subject(s) - resveratrol , bioavailability , chemistry , shoot , chromatography , in vivo , urine , high performance liquid chromatography , pharmacology , food science , biochemistry , botany , biology , microbiology and biotechnology
Scope Grapevine‐shoot extract Vineatrol30 contains abundant resveratrol monomers and oligomers with health‐promoting potential. However, the oral bioavailability of these compounds in humans is low (˂1–2%). The aim of this study was to improve the oral bioavailability of resveratrol from vineatrol by micellar solubilization. Methods and results Twelve healthy volunteers (six women, six men) randomly ingested a single dose of 500 mg vineatrol (30 mg trans ‐resveratrol, 75 mg trans ‐ε‐viniferin) as native powder or liquid micelles. Plasma and urine were collected at baseline and over 24 h after intake. Resveratrol and viniferin were analyzed by HPLC. The area under the plasma concentration–time curve (AUC) and mean maximum plasma trans ‐resveratrol concentrations were 5.0‐fold and 10.6‐fold higher, respectively, after micellar supplementation relative to the native powder. However, no detectable amounts of trans ‐ε‐viniferin were found in either plasma or urine. The transepithelial permeability of trans ‐resveratrol and trans ‐ε‐viniferin across differentiated Caco‐2 monolayers was consistent to the absorbed fractions in vivo. Conclusion The oral bioavailability of trans ‐resveratrol from the grapevine‐shoot extract Vineatrol30 was significantly increased using a liquid micellar formulation, without any treatment‐related adverse effects, making it a suitable system for improved supplementation of trans ‐resveratrol.