Premium
Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses
Author(s) -
Mathias Mariana Giaretta,
CoelhoLandell Carolina de Almeida,
ScottBoyer MariePier,
Lacroix Sébastien,
Morine Melissa J.,
Salomão Roberta Garcia,
Toffano Roseli Borges Donegá,
Almada Maria Olímpia Ribeiro do Vale,
Camarneiro Joyce Moraes,
Hillesheim Elaine,
Barros Tamiris Trevisan,
CameloJunior José Simon,
Campos Giménez Esther,
Redeuil Karine,
Goyon Alexandre,
Bertschy Emmanuelle,
Lévêques Antoine,
Oberson JeanMarie,
Giménez Catherine,
Carayol Jerome,
Kussmann Martin,
Descombes Patrick,
Métairon Slyviane,
Draper Colleen Fogarty,
Conus Nelly,
Mottaz Sara Colombo,
Corsini Giovanna Zambianchi,
Myoshi Stephanie Kazu Brandão,
Muniz Mariana Mendes,
Hernandes Lívia Cristina,
Venâncio Vinícius Paula,
Antunes Lusania Maria Greggi,
da Silva Rosana Queiroz,
Laurito Taís Fontellas,
Rossi Isabela Ribeiro,
Ricci Raquel,
Jorge Jéssica Ré,
Fagá Mayara Leite,
Quinhoneiro Driele Cristina Gomes,
Reche Mariana Chinarelli,
Silva Paula Vitória Sozza,
Falquetti Letícia Lima,
da Cunha Thaís Helena Alves,
Deminice Thalia Manfrin Martins,
Tambellini Tâmara Hambúrguer,
Souza Gabriela Cristina Arces,
Oliveira Mariana Moraes,
NogueiraPileggi Vicky,
Matsumoto Marina Takemoto,
Priami Corrado,
Kaput Jim,
Monteiro Jacqueline Pontes
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201700613
Subject(s) - micronutrient , multivitamin , anthropometry , medicine , intervention (counseling) , vitamin , population , vitamin d and neurology , environmental health , physiology , gerontology , pathology , psychiatry
Scope Micronutrients are in small amounts in foods, act in concert, and require variable amounts of time to see changes in health and risk for disease. These first principles are incorporated into an intervention study designed to develop new experimental strategies for setting target recommendations for food bioactives for populations and individuals. Methods and results A 6‐week multivitamin/mineral intervention is conducted in 9–13 year olds. Participants (136) are (i) their own control ( n ‐of‐1); (ii) monitored for compliance; (iii) measured for 36 circulating vitamin forms, 30 clinical, anthropometric, and food intake parameters at baseline, post intervention, and following a 6‐week washout; and (iv) had their ancestry accounted for as modifier of vitamin baseline or response. The same intervention is repeated the following year (135 participants). Most vitamins respond positively and many clinical parameters change in directions consistent with improved metabolic health to the intervention. Baseline levels of any metabolite predict its own response to the intervention. Elastic net penalized regression models are identified, and significantly predict response to intervention on the basis of multiple vitamin/clinical baseline measures. Conclusions The study design, computational methods, and results are a step toward developing recommendations for optimizing vitamin levels and health parameters for individuals.