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Response of Red Blood Cell Folate to Supplementation in Nonpregnant Women is Predictable: A Proposal for Personalized Supplementation
Author(s) -
Obeid Rima,
Schön Christiane,
Wilhelm Manfred,
Shrestha Rajiv P.,
Pilz Stefan,
Pietrzik Klaus
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201700537
Subject(s) - interquartile range , red blood cell , medicine , pregnancy , folic acid , cohort , endocrinology , biology , genetics
Scope We modeled red blood cell (RBC)‐folate response to supplementation and developed personalized folate supplementation concepts. Methods and results The changes of RBC‐folate were modeled in a time‐ (4 or 8 weeks) and dose‐ (400 or 800 μg d −1 folate) dependent manner. Post‐supplementation RBC‐folate levels were predicted from folate‐loading capacities (= measured RBC‐folate – [baseline RBC‐folate × RBC‐survival]). The prediction equations were validated in 119 participants. The median increase of RBC‐folate was higher in the 800 μg d −1 than in the 400 μg d −1 group (275 vs 169 nmol L −1 after 4 weeks, and 551 vs 346 nmol L −1 after 8 weeks). Medians (interquartile range) of RBC‐folate loading were (4 weeks: 299 (160) vs 409 (237) nmol L −1 ) and (8 weeks: 630 (134) versus 795 (187) nmol L −1 ) in the 400 and 800 μg d −1 group, respectively. The individual measured and predicted RBC‐folate values (after 4 weeks/400 μg d −1 = 25 + 1.27 × baseline RBC‐folate) and (after 4 weeks/800 μg d −1 = 65 + 1.41 × baseline RBC‐folate) did not differ significantly. The measured and predicted concentrations showed high agreement in the validation cohort. Conclusions The models can guide nutritional recommendations in women when baseline RBC‐folate concentrations are measured and the time to pregnancy between 4 and 8 weeks.