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Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled Trial
Author(s) -
BarberChamoux Nicolas,
Milenkovic Dragan,
Verny MarieAnne,
Habauzit Véronique,
Pereira Bruno,
Lambert Céline,
Richard Damien,
Boby Céline,
Mazur Andrzej,
Lusson Jean René,
Dubray Claude,
Morand Christine
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201700418
Subject(s) - curcumin , crossover study , peripheral blood mononuclear cell , medicine , randomized controlled trial , placebo , population , blood pressure , immune system , physiology , immunology , pharmacology , biology , pathology , in vitro , biochemistry , alternative medicine , environmental health
Scope Curcumin exerts biological activities of interest in cardiovascular prevention. However, its vascular protective effect is still poorly investigated in humans. The present study aims to assess vascular effect of an acute intake of curcumin and its nutrigenomic impact in circulating immune cells. Methods and results In a randomized, double‐blind, crossover design, 18 healthy smokers consume a placebo or a 5‐g curcumin. Before and 2 h after the intake, vascular function measurements are performed by using flow‐mediated dilation (FMD). In addition, endothelial function in the microcirculation and blood pressure are evaluated. Plasma curcumin concentrations and changes in gene expression in peripheral blood mononuclear cells (PBMC) are analyzed. No significant effect of curcumin on FMD is observed when considering the entire study population, mainly due to a high interindividual variability. A subgroup analysis according to the gender or the cardiovascular‐risk score reveals a significant effect of curcumin on FMD in women and in subjects presenting lower cardiovascular risk. No change in gene expression is observed when data are analyzed for all volunteers but changes in expression are observed when analyzed according to gender. Conclusions This clinical trial highlights that a substantial variability in efficacy of curcumin exists across individuals.