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Serum carotenoids and colorectal cancer risk: A case‐control study in Guangdong, China
Author(s) -
Huang Jing,
Lu MinShan,
Fang YuJing,
Xu Ming,
Huang WuQing,
Pan ZhiZhong,
Chen YuMing,
Zhang CaiXia
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201700267
Subject(s) - medicine , colorectal cancer , lutein , odds ratio , zeaxanthin , quartile , confidence interval , carotenoid , case control study , colorectal adenoma , lycopene , confounding , population , gastroenterology , cancer , biology , food science , environmental health
Scope Previous epidemiological studies on the association between circulating carotenoids and the risk of colorectal cancer drew inconclusive conclusions. This study aimed to examine serum carotenoids in relation to colorectal cancer risk in a Chinese population. Methods and results One case‐control study beginning from July 2010, consecutively recruited 538 eligible colorectal cancer cases and 564 age (5‐year interval) and sex frequency‐matched controls. Serum levels of α‐carotene, β‐carotene, β‐cryptoxanthin, lycopene and lutein/zeaxanthin were detected by HPLC. Unconditional logistic regression was used to estimate the odds ratio (OR) and 95% confidence internal (CI) after adjusting for various confounders. Serum levels of α‐carotene, β‐cryptoxanthin and lycopene were found to be inversely associated with colorectal cancer risk. The adjusted ORs of the highest quartile relative to the lowest quartile serum level were 0.49 (95% CIs 0.33–0.72) for α‐carotene, 0.44 (95% CIs 0.29–0.66) for β‐cryptoxanthin, and 0.36 (95% CIs 0.24–0.54) for lycopene, respectively. The association between serum β‐carotene, lutein/zeaxanthin and colorectal cancer risk was not statistically significant. Conclusion The results indicated that the incidence of colorectal cancer was associated with lower serum levels of α‐carotene, β‐cryptoxanthin and lycopene among Chinese population residing in Guangdong.