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Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high‐fat diet‐fed mice
Author(s) -
Suk Sujin,
Kwon Gyoo Taik,
Lee Eunjung,
Jang Woo Jung,
Yang Hee,
Kim Jong Hun,
Thimmegowda N. R.,
Chung MinYu,
Kwon Jung Yeon,
Yang Seunghee,
Kim Jason K.,
Park Jung Han Yoon,
Lee Ki Won
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201700139
Subject(s) - adipose tissue , adipogenesis , inflammation , ampk , oil red o , lipid metabolism , endocrinology , medicine , obesity , in vivo , white adipose tissue , chemistry , pharmacology , biology , kinase , protein kinase a , biochemistry , microbiology and biotechnology
Scope Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti‐obesity effect of gingerenone A (GA) in diet‐induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). Methods and results Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3‐L1 cells among ginger components tested at a single concentration (40 μM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP‐activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro‐inflammatory cytokines. Conclusion These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.