Premium
Fasting serum hippuric acid is elevated after bilberry ( Vaccinium myrtillus ) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
Author(s) -
Mello Vanessa DF,
Lankinen Maria A,
Lindström Jaana,
PuupponenPimiä Riitta,
Laaksonen David E,
Pihlajamäki Jussi,
Lehtonen Marko,
Uusitupa Matti,
Tuomilehto Jaakko,
Kolehmainen Marjukka,
Törrönen Riitta,
Hanhineva Kati
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201700019
Subject(s) - hippuric acid , bilberry , vaccinium myrtillus , medicine , type 2 diabetes , metabolite , endocrinology , insulin , diabetes mellitus , anthocyanin , chemistry , urine , food science , biology , botany
Scope Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry‐enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results Hippuric acid was measured with LC‐QTOF‐MS metabolite profiling analysis from fasting serum samples at baseline and after an 8‐week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet ( n = 15), an SRC diet ( n = 20) or a control diet ( n = 12). Fasting serum hippuric acid increased significantly (3.5‐fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration ( r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study ( n = 198). Conclusion Fasting serum hippuric acid is increased after consumption of anthocyanin‐rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β‐cell function.