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Back cover: Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells
Author(s) -
Sun Yue,
Wu Xian,
Cai Xiaokun,
Song Mingyue,
Zheng Jinkai,
Pan Che,
Qiu Peiju,
Zhang Lijuan,
Zhou Shuangde,
Tang Zhonghai,
Xiao Hang
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201670095
Subject(s) - pterostilbene , resveratrol , apoptosis , metabolite , inhibitory postsynaptic potential , colorectal cancer , cell cycle , demethylation , cell , cancer , pharmacology , biology , chemistry , cancer research , medicine , biochemistry , endocrinology , gene , gene expression , dna methylation
Mol. Nutr. Food Res . 2016, 60 , 1924–1932. DOI: 10.1002/mnfr.201500989 Dietary pterostilbene, a resveratrol derivative found in blueberries, is transformed to pinostilbene via demethylation in mice. The level of pinostilbene in the colonic mucosa of pterostilbene‐fed mice is relatively high, and at that level, pinostilbene inhibits human colon cancer cell growth by inducing cell cycle arrest and apoptosis.