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ERK5/HDAC5‐mediated, resveratrol‐, and pterostilbene‐induced expression of MnSOD in human endothelial cells
Author(s) -
Gan Woting,
Dang Yanqi,
Han Xin,
Ling Shuang,
Duan Ju,
Liu Jun,
Xu JinWen
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201670021
Subject(s) - pterostilbene , resveratrol , klf2 , microbiology and biotechnology , phosphorylation , ampk , chemistry , biology , biochemistry , gene expression , protein kinase a , gene
Mol. Nutr. Food Res. 2016, 60, 266–277. DOI: 10.1002/mnfr.201500466 Resveratrol and pterostilbene, present in fruits, red wine and some Chinese medicine herbs, activate MnSOD expression, and stimulate LKB1, AMPKα, ERK5 phosphorylation and HDAC5 and KLF2 expression in endothelial cells. Furthermore, two stilbenes promote KLF2 binding to human MnSOD promoter. These findings reveal a new mechanism underlying the anti‐aging effect two stilbenes exert on vascular endothelial cells.