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Lycopene and tomato powder supplementation similarly inhibit high‐fat diet induced obesity, inflammatory response, and associated metabolic disorders
Author(s) -
Fenni Soumia,
Hammou Habib,
Astier Julien,
Bonnet Lauriane,
Karkeni Esma,
Couturier Charlène,
Tourniaire Franck,
Landrier JeanFrançois
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201601083
Subject(s) - lycopene , adipose tissue , medicine , endocrinology , proinflammatory cytokine , obesity , context (archaeology) , lipolysis , chemistry , biology , inflammation , carotenoid , food science , paleontology
Scope Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity‐associated disorders. Methods and results Male C57BL/J6 mice were assigned into four groups to receive: control diet (CD), high fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks. In HFD condition, lycopene and TP supplementation significantly reduced adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids, 8‐iso‐prostaglandin GF2α and improved glucose homeostasis, but did not affect total body weight. Lycopene and TP supplementation prevented HFD‐induced hepatosteatosis and hypertrophy of adipocytes. Lycopene and TP decreased HFD‐induced proinflammatory cytokine mRNA expression in the liver and in the epididymal adipose tissue. The anti‐inflammatory effect of lycopene and TP was related to a reduction in the phosphorylation levels of IκB, and p65, and resulted in a decrease of inflammatory proteins in adipose tissue. Conclusion These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity‐associated pathologies.