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trans ‐Lycopene from tomato juice attenuates inflammatory biomarkers in human plasma samples: An intervention trial
Author(s) -
ColmánMartínez Mariel,
MartínezHuélamo Miriam,
ValderasMartínez Palmira,
ArranzMartínez Sara,
AlmanzaAguilera Enrique,
Corella Dolores,
Estruch Ramón,
LamuelaRaventós Rosa M.
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201600993
Subject(s) - lycopene , carotenoid , medicine , population , biomarker , prospective cohort study , gastroenterology , food science , chemistry , biochemistry , environmental health
Scope The effect of carotenoids from tomato juice (TJ) on inflammatory biomarkers was evaluated by performing a 4‐week dose‐response nutritional trial in a population at high cardiovascular risk. Methods and results An open, prospective, randomized, cross‐over, and controlled clinical trial was carried out with 28 volunteers (mean age 69.7 ± 3.1 years; mean BMI 31.5 ± 3.6 kg/m 2 ) at high cardiovascular risk, which were assigned to consume daily for 4 weeks in random order: 200 mL (LD) or 400 mL (HD) of TJ, or water as a control (C), with a 21‐day wash‐out period between each intervention. Blood samples were collected at baseline (B) and after each intervention. Endpoints included significant changes in plasmatic carotenoids, and adhesion molecules ICAM‐1, and VCAM‐1, as well as a tendency to decrease the chemokine IL‐8. Compared to C, concentration of ICAM‐1, and VCAM‐1 were significantly lower ( p ˂ 0.001), after each TJ intervention. Decreases were correlated remarkably with the trans‐ lycopene, while the other carotenoids present in TJ have presented a minor association or no association with changes in these molecules. Conclusion trans ‐Lycopene from TJ may attenuate the risk of cardiovascular disease by reducing the concentration of important inflammatory molecules related to atherosclerosis.