Premium
An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats
Author(s) -
Zheng Wenya,
Hengevoß Jonas,
Soukup Sebastian T.,
Kulling Sabine E.,
Xie Mingyong,
Diel Patrick
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201600843
Subject(s) - myod , ovariectomized rat , myogenin , skeletal muscle , endocrinology , medicine , anabolism , soleus muscle , stimulation , gastrocnemius muscle , chemistry , myogenesis , estrogen
Scope This study was to investigate anabolic adaptation of skeletal muscle in response to an isoflavone (ISO) enriched diet, training and their combinations in ovariectomized (OVX) rats. Methods and results Female Wistar rats were sedentary, performed treadmill uphill running, received ISOs, or a combination of ISOs and running after ovariectomy. Body weight was increased by OVX. Both ISO and training treatment antagonized this increase. The weights of soleus and gastrocnemius muscles were increased only when training and ISOs were combined. In soleus muscle insulin‐like growth factor (IGF)‐1R, MyoD and Myogenin expressions were only up‐regulated by training in Sham groups. However, a stimulation of IGF‐1R and MyoD expression could be observed when ISOs and training were combined. In gastrocnemius muscle MyoD and Myogenin expressions were stimulated by either training or ISOs. Additive effects were detected when combining the two interventions. Conclusion Our results indicate that the combination of ISOs and exercise is more efficient in increasing relative skeletal muscle mass and the expression of molecular markers related to anabolic adaptation in the skeletal muscle of female rats.