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Use of antibiotics is associated with lower enterolactone plasma concentration
Author(s) -
Bolvig Anne K.,
Kyrø Cecilie,
Nørskov Natalja P.,
Eriksen Anne K.,
Christensen Jane,
Tjønneland Anne,
Knudsen Knud E. Bach,
Olsen Anja
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201600566
Subject(s) - enterolactone , antibiotics , plasma concentration , chemistry , microbiology and biotechnology , food science , medicine , biology , phytoestrogens , estrogen
Scope High enterolactone levels may have health benefits in relation to risk of noncommunicable diseases. Enterolactone is produced by the colonic microbiota after intake of lignans and treatment with antimicrobials may result in altered enterolactone production. This study investigates the association between antibiotic use and enterolactone concentration. Methods and results Using LC–MS/MS, enterolactone concentrations were quantified in plasma samples from 2237 participants from the Diet, Cancer and Health cohort. The participants were healthy at enrollment, but were later diagnosed with cancer. At enrollment, participants had blood drawn and completed a food frequency questionnaire and lifestyle questionnaire. Antibiotic use was assessed as reimbursed antibiotic prescriptions up to 12 months before enrollment. Antibiotic use ≤3 months before enrollment was associated with a 41% (Δ crude : –41; 95% CI: –52, –28) lower enterolactone concentration in women and 12% in men (Δ crude : –12; 95% CI: –31, 11), while antibiotic use >3–12 months before enrollment was associated with 26% lower enterolactone in women (Δ crude : –26; 95% CI: –37, –14) and 14% in men (Δ crude : –14; 95% CI: –28, 1). Conclusion Use of antibiotics up to 12 months before enrollment was associated with lower plasma enterolactone levels, especially among women.