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Perinatal maternal high‐fat diet promotes alterations in hepatic lipid metabolism and resistance to the hypolipidemic effect of fish oil in adolescent rat offspring
Author(s) -
Oliveira Lorraine S.,
Souza Luana L.,
Souza Aline F. P.,
Cordeiro Aline,
Kluck George E. G.,
Atella Georgia C.,
Trevenzoli Isis H.,
PazosMoura Carmen C.
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201600171
Subject(s) - offspring , endocrinology , medicine , weaning , fish oil , biology , cholesterol , insulin resistance , triglyceride , pregnancy , obesity , fish <actinopterygii> , genetics , fishery
Scope Maternal high‐fat diet (HFD) promotes obesity and metabolic disturbances in offspring at weaning and adult life. We investigated metabolic consequences of maternal HFD in adolescent rat offspring and the potential benefic effects of fish oil (FO) ( n ‐3 polyunsaturated fatty acid source). Methods and results Female rats received isocaloric, standard diet (STD: 9% fat) or HFD (28.6%) before mating, and throughout pregnancy and lactation. After weaning, male offspring received standard diet and, from 25th to 45th day, received oral administration of soybean oil (SO) or FO. HFD offspring showed higher body weight and adiposity, which was not attenuated by FO. In STD offspring, FO reduced serum triglyceride and cholesterol, as expected, but not in HFD offspring. Liver of HFD offspring groups showed increased free cholesterol and FO‐treated HFD group showed lower expression of Abcg8 , suggesting decreased cholesterol biliary excretion. HFD offspring presented higher hepatic expression of lipogenic markers, Srebf1 mRNA and acetyl CoA carboxylase (ACC). Serum n ‐3 PUFA were decreased in FO‐treated HFD compared to FO‐treated STD offspring, which may explain the reduced hypolipidemic FO effect. Conclusion Maternal HFD impaired the ability of FO to reduce adiposity and serum lipids in adolescent offspring, suggesting a potential predisposition to future development of metabolic disorders