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Isoflavone supplementation in postmenopausal women does not affect leukocyte LDL receptor and scavenger receptor CD36 expression: A double‐blind, randomized, placebo‐controlled trial
Author(s) -
Engelbert Ann Katrin,
Soukup Sebastian T.,
Roth Alexander,
Hoffmann Nadine,
Graf Daniela,
Watzl Bernhard,
Kulling Sabine E.,
Bub Achim
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201600019
Subject(s) - cd36 , medicine , endocrinology , scavenger receptor , adipose tissue , ldl receptor , receptor , receptor expression , blood lipids , cholesterol , chemistry , lipoprotein
Scope Isoflavones are discussed to improve serum lipoproteins and body composition and to reduce cardiovascular disease risk in postmenopausal women (PMW). LDL receptors (LDLR) and scavenger receptor CD36 (CD36) play a pivotal role in the regulation of plasma LDL‐cholesterol concentrations (LDL‐chol). We investigated the impact of isoflavones on the receptor expression of both receptors in leukocytes of PMW. Methods and results A randomized, double‐blind, placebo‐controlled trial in parallel design was conducted to assess the effects of an isoflavone‐enriched soy extract (117.4 mg/day isoflavone aglycone equivalents) for 12 weeks on serum LDL‐chol, LDLR, and CD36 expression on leukocytes in 170 healthy PMW. Baseline and after 12 weeks, blood lipid concentrations, anthropometric data and body composition were determined. Receptor expression on leukocytes was measured by means of flow cytometry. After the intervention, no significant differences were found for LDLR and CD36 expression on leukocytes. A significant increase of serum LDL‐chol was shown for the isoflavone group ( p = 0.03) after 12 weeks. Body fat content and VAT were not affected. Conclusion Isoflavone supplementation for 12 weeks did not change LDLR and CD36 expression on leukocytes of PMW and did not affect body fat content and visceral adipose tissue (VAT), but slightly increased serum LDL‐chol.