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(‐)‐Epigallocatechin‐3‐gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss
Author(s) -
Bitzer Zachary T.,
Elias Ryan J.,
VijayKumar Matam,
Lambert Joshua D.
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201501042
Subject(s) - colitis , epigallocatechin gallate , inflammatory bowel disease , inflammation , proinflammatory cytokine , medicine , ulcerative colitis , weight loss , endocrinology , chemistry , context (archaeology) , tumor necrosis factor alpha , pharmacology , polyphenol , biochemistry , obesity , antioxidant , biology , disease , paleontology
Scope (‐)‐Epigallocatechin‐3‐gallate (EGCG) has been reported to have putative health effects including the prevention of inflammation and obesity. Historically, polyphenols have been regarded as antinutritionals and while such effects may be beneficial in obese subjects, they may be deleterious in nutritionally compromised individuals. Methods and results We examined the effect of EGCG in the dextran sulfate sodium (DSS)‐treated mouse model of ulcerative colitis. Following induction of colitis, mice were treated with EGCG (3.2 mg/g) as the sole source of drinking fluid for 3 days. EGCG treatment mitigated DSS‐induced colon shortening and spleen enlargement. EGCG also decreased colonic protein levels of IL‐1β, IL‐6, and tumor necrosis factor‐α, as well as colonic lipid peroxides compared to DSS‐treated controls. We observed that EGCG reduced DSS‐induced gastrointestinal permeability. These beneficial effects were offset by enhanced body weight loss in EGCG‐treated mice compared to DSS‐treated controls. These effects were related to decreased protein and lipid digestion in EGCG‐treated mice compared to DSS‐treated controls. Conclusions Our results suggest that although EGCG may exert anti‐inflammatory effects, its ability to modulate macronutrient digestion may represent a dose‐limiting adverse effect that must be considered in the context of its use for treating inflammatory bowel disease.