Premium
Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors
Author(s) -
Sheflin Amy M.,
Borresen Erica C.,
Kirkwood Jay S.,
Boot Claudia M.,
Whitney Alyssa K.,
Lu Shen,
Brown Regina J.,
Broeckling Corey D.,
Ryan Elizabeth P.,
Weir Tiffany L.
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500905
Subject(s) - gut flora , food science , firmicutes , bacteroidetes , bran , meal , biology , colorectal cancer , fermentation , overweight , medicine , propionate , prebiotic , obesity , physiology , cancer , bacteria , biochemistry , raw material , ecology , genetics , 16s ribosomal rna
Scope Heat‐stabilized rice bran (SRB) and cooked navy bean powder (NBP) contain a variety of phytochemicals that are fermented by colonic microbiota and may influence intestinal health. Dietary interventions with these foods should be explored for modulating colorectal cancer risk. Methods and results A randomized‐controlled pilot clinical trial investigated the effects of eating SRB (30 g/day) or cooked navy bean powder (35 g/day) on gut microbiota and metabolites (NCT01929122). Twenty‐nine overweight/obese volunteers with a prior history of colorectal cancer consumed a study‐provided meal and snack daily for 28 days. Volunteers receiving SRB or NBP showed increased gut bacterial diversity and altered gut microbial composition at 28 days compared to baseline. Supplementation with SRB or NBP increased total dietary fiber intake similarly, yet only rice bran intake led to a decreased Firmicutes:Bacteroidetes ratio and increased SCFA (propionate and acetate) in stool after 14 days but not at 28 days. Conclusion These findings support modulation of gut microbiota and fermentation byproducts by SRB and suggest that foods with similar ability to increase dietary fiber intake may not have equal effects on gut microbiota and microbial metabolism.