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Triterpene alcohols and sterols from rice bran reduce postprandial hyperglycemia in rodents and humans
Author(s) -
Okahara Fumiaki,
Suzuki Junko,
Hashizume Kohjiro,
Osaki Noriko,
Shimotoyodome Akira
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500897
Subject(s) - postprandial , medicine , endocrinology , bran , glut2 , chemistry , brown rice , biology , biochemistry , glucose transporter , diabetes mellitus , food science , insulin , raw material , organic chemistry
Scope Hyperglycemia is a major public health problem worldwide and there is increasing demand for prevention of postprandial hyperglycemia in diabetic, prediabetic, and healthy humans. Methods and results We investigated whether rice bran and triterpene alcohol and sterol preparation (TASP) lowered hyperglycemia in mice and humans. Brown rice and white rice supplemented with TASP lowered the postprandial hyperglycemia in humans. TASP and its components (cycloartenol [CA], 24‐methylene cycloartanol, β‐sitosterol, and campesterol) decreased postprandial hyperglycemia in C57BL/6J mice. Glucose transport into everted rat intestinal sacs and human HuTu80 cells transfected with sodium–glucose cotransporter‐1 (SGLT1) was significantly reduced by the addition of CA. Intracellular localization analysis suggested that SGLT1 translocation to the apical plasma membrane was inhibited when the cells were treated with CA. Conclusions We demonstrated for the first time that TASP from rice bran lowered postprandial hyperglycemia in mice and humans. The smaller increase in blood glucose following TASP consumption may be due to the CA‐induced decrease in glucose absorption from the intestine, which may be related to decreased membrane translocation of SGLT1.