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Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet
Author(s) -
Kaakoush Nadeem O.,
Martire Sarah I.,
Raipuria Mukesh,
Mitchell Hazel M.,
Nielsen Shaun,
Westbrook R. Fred,
Morris Margaret J.
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500815
Subject(s) - cafeteria , gut flora , western diet , biology , medicine , physiology , endocrinology , obesity , immunology , pathology
Scope Overconsumption of energy‐rich food is a major contributor to the obesity epidemic. The eating habits of many people are characterized by the cycling between overconsumption of energy‐rich foods and dieting, the effects of which on the microbiota are currently unknown. Methods and results We compared the fecal microbiota of rats either continuously fed chow or palatable cafeteria diet to a “cycled” group switched between the two diets (chow for 4, cafeteria for 3 days/wk, n = 12/group) over 16 wk. Enriched bacterial metabolic pathways were predicted, and a range of metabolic parameters was correlated to microbial taxa and pathways. Cycled rats showed large excursions in food intake on each diet switch. When switched from chow to cafeteria, they overconsumed, and when switched back to chow they underconsumed relative to those maintained on the two diets. Metabolic parameters of cycled rats were intermediate between those of the other diet groups ( p < 0.05). The microbiota of cycled rats was nearly indistinguishable from rats under constant cafeteria diet, and both groups were significantly different to the chow group. Correlation analyses identified microbial metabolic pathways associated with an obese phenotype. Conclusion These data suggest that continuous or intermittent exposure to palatable foods have similar effects on the gut microbiota.