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High dietary cholesterol intake during lactation promotes development of fatty liver in offspring of mice
Author(s) -
Tsuduki Tsuyoshi,
Yamamoto Kazushi,
Hatakeyama Yu,
Sakamoto Yu
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500736
Subject(s) - offspring , lactation , endocrinology , dyslipidemia , medicine , fatty liver , insulin resistance , cholesterol , metabolic syndrome , biology , obesity , pregnancy , genetics , disease
Scope We have previously demonstrated in mice that a maternal high fat diet during lactation enhances the susceptibility of offspring to obesity and fatty liver. A causative molecule, however, is yet to be identified. Therefore, we examined the role of cholesterol, the dietary intake of which increases with consumption of a high fat diet. Excessive cholesterol intake is involved in the development of fatty liver, which in turn becomes a risk factor for metabolic syndrome, which includes obesity, insulin resistance, and dyslipidemia. However, our knowledge of the influences on offspring of excessive maternal cholesterol intake alone during pregnancy and lactation is limited. We examined how excessive maternal cholesterol intake during lactation influences susceptibility of the offspring to metabolic syndrome in mice. Results High cholesterol intake promoted triacylglycerol accumulation in the liver of offspring ( p < 0.05), and elevated expression of molecules involved in hepatic lipoprotein influx was identified as the underlying mechanism. Conclusion These findings demonstrate that excessive maternal cholesterol intake during lactation enhances the susceptibility of the offspring to development of fatty liver.