Premium
Gene‐diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men
Author(s) -
Takkunen Markus J.,
Mello Vanessa D.,
Schwab Ursula S.,
Kuusisto Johanna,
Vaittinen Maija,
Ågren Jyrki J.,
Laakso Markku,
Pihlajamäki Jussi,
Uusitupa Matti I. J.
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500594
Subject(s) - polyunsaturated fatty acid , docosapentaenoic acid , eicosapentaenoic acid , fads2 , docosahexaenoic acid , biology , fatty acid , endocrinology , medicine , biochemistry , chemistry
Scope Limited information exists on how the relationship between dietary intake of fat and fatty acids in erythrocytes and plasma is modulated by polymorphisms in the FADS gene cluster. We examined gene‐diet interaction of total marine PUFA intake with a known gene encoding Δ‐5 desaturase enzyme (FADS1) variant (rs174550) for fatty acids in erythrocyte membranes and plasma phospholipids (PL), cholesteryl esters (CE), and triglycerides (TG). Methods and results In this cross‐sectional study, fatty acid compositions were measured using GC, and total intake of polyunsaturated fat from fish and fish oil was estimated using a food frequency questionnaire in a subsample ( n = 962) of the Metabolic Syndrome in Men Study. We found nominally significant gene‐diet interactions for eicosapentaenoic acid (EPA, 20:5 n ‐3) in erythrocytes ( p interaction = 0.032) and for EPA in plasma PL ( p interaction = 0.062), CE ( p interaction = 0.035), and TG ( p interaction = 0.035), as well as for docosapentaenoic acid (22:5 n ‐3) in PL ( p interaction = 0.007). After excluding omega‐3 supplement users, we found a significant gene‐diet interaction for EPA in erythrocytes ( p interaction < 0.003). In a separate cohort of the Kuopio Obesity Surgery Study, the same locus was strongly associated with hepatic mRNA expression of FADS1 ( p = 1.5 × 10 −10 ). Conclusion FADS1 variants may modulate the relationship between marine fatty acid intake and circulating levels of long‐chain omega‐3 fatty acids.