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Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize‐based foods and living in high exposure communities in Guatemala
Author(s) -
Riley Ronald T.,
Torres Olga,
Matute Jorge,
Gregory Simon G.,
AshleyKoch Allison E.,
Showker Jency L.,
Mitchell Trevor,
Voss Kenneth A.,
Maddox Joyce R.,
Gelineauvan Waes Janee B.
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500499
Subject(s) - fumonisin b1 , ceramide synthase , urine , ceramide , sphingolipid , fumonisin , zoology , chemistry , medicine , biology , endocrinology , physiology , food science , mycotoxin , biochemistry , apoptosis
Scope Fumonisin (FB) occurs in maize and is an inhibitor of ceramide synthase (CerS). We determined the urinary FB 1 (UFB 1 ) and sphingoid base 1‐phosphate levels in blood from women consuming maize in high and low FB exposure communities in Guatemala. Methods and results FB 1 intake was estimated using the UFB 1 . Sphinganine 1‐phosphate (Sa 1‐P), sphingosine 1‐phosphate (So 1‐P), and the Sa 1‐P/So 1‐P ratio were determined in blood spots collected on absorbent paper at the same time as urine collection. In the first study, blood spots and urine were collected every 3 months (March 2011 to February 2012) from women living in low (Chimaltenango and Escuintla) and high (Jutiapa) FB exposure communities (1240 total recruits). The UFB 1 , Sa 1‐P/So 1‐P ratio, and Sa 1‐P/mL in blood spots were significantly higher in the high FB 1 intake community compared to the low FB 1 intake communities. The results were confirmed in a follow‐up study (February 2013) involving 299 women living in low (Sacatepéquez) and high (Santa Rosa and Chiquimula) FB exposure communities. Conclusions High levels of FB 1 intake are correlated with changes in Sa 1‐P and the Sa 1‐P/So 1‐P ratio in human blood in a manner consistent with FB 1 inhibition of CerS.