Premium
Anti‐inflammatory and anti‐arthritic effects of pentacyclic triterpenoids maslinic acid through NF‐κB inactivation
Author(s) -
Fukumitsu Satoshi,
Villareal Myra O.,
Fujitsuka Takashi,
Aida Kazuhiko,
Isoda Hiroko
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500465
Subject(s) - arthritis , inflammation , tumor necrosis factor alpha , olea , chemistry , anti inflammatory , pharmacology , medicine , immunology , biology , paleontology
Scope Consumption of olives ( Olea europaea L.), including table olives and oil, is associated with low incidence of inflammation‐related diseases. In this study, the effects of maslinic acid (MA), the main constituent of olive pomace, on the expression of genes and proteins involved in inflammatory activity in RAW 264.7 cells were investigated. Furthermore, the effect of MA on carrageenan‐induced paw edema and collagen antibody induced arthritis in mice was determined. Methods and results We confirmed the suppressive effects of MA on LPS‐induced tumor necrosis factor α production and on the expression of inflammatory response associated genes in RAW 264.7 cells. We also clarified the suppressive effect of MA on LPS‐induced nuclear factor‐kappa B activation as well as the phosphorylation of IκB‐α. Furthermore, MA (200 mg/kg in the edema model or 100 mg/kg in the arthritis model) exerted anti‐inflammatory and antiarthritis effects as shown by the suppression of paw edema, arthritis score, inflammatory cells, and destruction of synovium in knee joints. Conclusion Olive products containing MA are useful as a new preventive and therapeutic food ingredient for inflammatory and arthritic diseases.