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Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health‐related biochemical parameters: Results of human intervention trials
Author(s) -
Ferk Franziska,
Mišík Miroslav,
Nersesyan Armen,
Pichler Christoph,
Jäger Walter,
Szekeres Thomas,
Marculescu Rodrig,
Poulsen Henrik E.,
Henriksen Trine,
Bono Roberto,
Romanazzi Valeria,
AlSerori Halh,
Biendl Martin,
Wagner KarlHeinz,
Kundi Michael,
Knasmüller Siegfried
Publication year - 2016
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500355
Subject(s) - xanthohumol , flavonoid , pharmacology , dna damage , guanosine , chemistry , antioxidant , biochemistry , dna , biology , ecology , key (lock)
Scope Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti‐inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health‐related parameters in humans. Methods and results The effects of the flavonoid were investigated in a randomized crossover intervention trial ( n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health‐related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine and 8‐oxo‐guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow‐up study with pure XN ( n = 10) with a parallel design. Other biochemical parameters reflecting the redox‐ and hormonal status and lipid‐ and glucose metabolism were not altered after the intervention. Conclusion Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.