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Furostanolic saponins from Trigonella foenum‐graecum alleviate diet‐induced glucose intolerance and hepatic fat accumulation
Author(s) -
Hua Yinan,
Ren Sidney Y.,
Guo Rui,
Rogers Olivia,
Nair Rama P.,
Bagchi Debasis,
Swaroop Anand,
Nair Sreejayan
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500197
Subject(s) - insulin resistance , medicine , trigonella , endocrinology , triglyceride , insulin tolerance test , glucose tolerance test , insulin , protein kinase b , impaired glucose tolerance , carbohydrate metabolism , insulin receptor , diabetes mellitus , chemistry , cholesterol , biochemistry , phosphorylation , traditional medicine , insulin sensitivity
Scope The objective of this study was to evaluate the effect of fenugreek furostanolic saponins (Fenfuro TM ) either alone or in combination with chlorogenic acid (GCB‐70 TM ) on insulin resistance in mice. Methods and results Male C57BL/6J mice were subjected to a normal or high‐fat diet (HFD) and were randomly assigned to receive Fenfuro TM , GCB‐70 TM , or their combination for 24 wk. Metabolic parameters, glucose tolerance, serum triglycerides, cardiac function, and hepatic insulin signaling were evaluated using indirect open‐circuit calorimetry, intraperitoneal glucose tolerance test, oil red O staining, echocardiography, and Western blotting, respectively. Intraperitoneal glucose tolerance test revealed glucose intolerance in the mice receiving HFD, which was attenuated by Fenfuro TM . Serum triglyceride that was elevated following an HFD was reconciled by both Fenfuro TM and the combination. HFD compromised myocardial contractile function, which was unaffected by the treatment. Insulin‐stimulated phosphorylation of Protein kinase B (AKT) in the liver was attenuated in mice receiving HFD, which was partially rescued by GCB‐70 TM . Neither treatment altered metabolic parameters or energy expenditure. Conclusion Collectively, our data suggest that fenugreek furostanolic saponins and green coffee bean extract may have potential benefits in treating insulin resistance and related conditions.