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Relation of allium vegetables intake with head and neck cancers: Evidence from the INHANCE consortium
Author(s) -
Galeone Carlotta,
Turati Federica,
Zhang ZuoFeng,
Guercio Valentina,
Tavani Alessandra,
Serraino Diego,
Brennan Paul,
Fabianova Eleonora,
Lissowska Jola,
Mates Dana,
Rudnai Peter,
Shangina Oxana,
SzeszeniaDabrowska Neonila,
Vaughan Thomas L.,
Kelsey Karl,
McClean Michael,
Levi Fabio,
Hayes Richard B.,
Purdue Mark P.,
Bosetti Cristina,
Brenner Hermann,
Pelucchi Claudio,
Lee YuanChin Amy,
Hashibe Mia,
Boffetta Paolo,
Vecchia Carlo
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201500042
Subject(s) - allium , head and neck , medicine , oncology , biology , surgery , horticulture
Scope Only a few studies analyzed the role of allium vegetables with reference to head and neck cancers (HNC), with mixed results. We investigated the potential favorable role of garlic and onion within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Methods and results We analyzed pooled individual‐level data from eight case‐control studies, including 4590 cases and 7082 controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between garlic and onion intakes and HNC risk. Compared with no or low garlic use, the ORs of HNC were 0.95 (95% CI 0.71–1.27) for intermediate and 0.74 (95% CI 0.55–0.99) for high garlic use ( p for trend = 0.02). The ORs of HNC for increasing categories of onion intake were 0.91 (95% CI 0.68–1.21) for >1 to ≤3 portions per week, and 0.83 (95% CI 0.60–1.13) for >3 portions per week ( p for trend = 0.02), as compared to <1 portion per week. We found an inverse association between high onion intake and laryngeal cancer risk (OR = 0.69; 95% CI 0.54–0.88), but no significant association for other subsites. Conclusion The results of this pooled‐analysis support a possible moderate inverse association between garlic and onion intake and HNC risk.