Premium
Digestive absorption of silicon, supplemented as orthosilicic acid–vanillin complex
Author(s) -
Marcowycz Aline,
Housez Béatrice,
Maudet Corinne,
Cazaubiel Murielle,
Rinaldi Guiseppe,
Croizet Karine
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400881
Subject(s) - vanillin , absorption (acoustics) , silicon , chemistry , silicon valley , nanotechnology , biochemistry , materials science , organic chemistry , business , composite material , finance , entrepreneurship
Scope Silicon (Si) is an abundant element on earth. It is found naturally in water in the form of orthosilicic acid (OSA), however this form is not stable under certain conditions such as in highly concentrated and non‐neutral pH solutions, which lead to its polymerization and reduced bioavailability. This study aimed to assess the bioavailability of Si from OSA stabilized by vanillin (OSA‐VC). Methods and results This was a single‐center, double‐blind, cross‐over randomized controlled trial. Fourteen healthy subjects were recruited and consumed either OSA‐VC or a placebo on two separate occasions. Blood and urine samples were collected during 6 h following ingestion and analyzed to determine Si absorption and excretion. Plasma Si area under the curve (0–6 h) was significantly higher after OSA‐VC ingestion compared to placebo ingestion ( p = 0.0002). Significantly higher urinary Si excretion was also reported over the 6‐h period after OSA‐VC ingestion compared to placebo ( p <0.0001). Approximately 21% of ingested Si was excreted in urine during this period. Conclusion Although many studies have investigated the metabolism and bioavailability of Si supplemented in foods or as a food ingredient, this was the first to investigate and demonstrate the digestibility of OSA administered in a complex form with vanillin.