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Suppression of 7,12‐dimethylbenz(a)anthracene‐induced mammary tumorigenesis by glyceollins
Author(s) -
Kim Bo Ram,
Seo JiYeon,
Sung MiKyung,
Park Jung Han Yoon,
Suh HwaJin,
Liu Kwang Hyeon,
Kim JongSang
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400726
Subject(s) - dmba , mammary tumor , carcinogenesis , carcinogen , chemistry , 7,12 dimethylbenz[a]anthracene , medicine , endocrinology , antioxidant , enzyme , cancer research , biology , biochemistry , cancer , breast cancer
Scope Our previous study showed that glyceollins induced phase 2 detoxifying and antioxidant enzymes. As chemical carcinogens can be detoxified by metabolic activity of phase 2 enzymes, subsequently decreasing their tumorigenic potential, we investigated whether 7,12‐dimethylbenz(a)anthracene (DMBA)‐induced mammary tumorigenesis could be attenuated by treatment with glyceollins in a mouse model. Methods and results Pretreatment with glyceollins (5 mg/kg body weight) caused a significant reduction in tumor formation and an increase in survival rate. The protective effect of glyceollins against DMBA‐induced tumorigenesis was found to be mainly associated with their potential to induce phase 2/antioxidant enzymes that are, in turn, regulated by the nuclear factor E2‐related factor 2 signaling pathway, and to a less extent to suppress phase 1 enzymes. As glyceollins increased the number of terminal end buds, a tumor‐prone mammary tissue type in mice, it is unlikely that they exert their antitumorigenic action through their estrogenic activity. Conclusion Glyceollins were found to have a protective effect in a chemically induced mammary tumor model.