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Anti‐obesogenic effects of calcium prevent changes in the GLP‐1 profile in adult rats primed by early weaning
Author(s) -
Quitete Fernanda Torres,
Nobre Jessica Lopes,
PeixotoSilva Nayara,
Moura Egberto Gaspar,
Lisboa Patricia Cristina,
Oliveira Elaine
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400666
Subject(s) - medicine , endocrinology , lactation , appetite , calcium , glucagon like peptide 1 , adipose tissue , weaning , peptide yy , glucagon like peptide 1 receptor , receptor , biology , type 2 diabetes , diabetes mellitus , agonist , neuropeptide , pregnancy , genetics , neuropeptide y receptor
Scope Gut peptides regulate appetite and adipogenesis. Early weaning (EW) leads to later development of obesity that can be prevented by calcium supplementation. We evaluated gut peptides that may have a role in the establishment of this dysfunction. Methods and results At birth, lactating Wistar rats were separated in: EW, lactating rats involved with a bandage interrupting the lactation during the last 4 days of standard lactation, and C (control) dams whose pups had free access to milk during throughout lactation. At 120 days old, half of EW group received calcium supplementation (EWCa); EW and C received standard diet. At 21 days old, EW presented higher glucagon‐like peptide 1 (GLP‐1) in plasma and glucagon‐like peptide 1 receptor (GLP1‐R) in adipose tissue and hypothalamus, but lower GLP‐1 and GLP1‐R in the gut. At 180 days old, GLP‐1 response to food intake was blunted in EW and restored by calcium. GLP‐1 in the gut was lower in EW and its receptor was lower in adipose tissue, and GLP1‐R was higher in the gut of calcium EW group. Conclusion Thus, EW had short‐ and long‐term effects upon GLP‐1 profile, which may have contributed to obesity development, hyperphagia, and insulin resistance due to its adipogenic and appetite control roles. Calcium supplementation was able to prevent most of the changes in GLP‐1 caused by EW.