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Breast cancer chemoprevention by dietary natural phenolic compounds: Specific epigenetic related molecular targets
Author(s) -
Pan MinHsiung,
Chiou YiSiou,
Chen LiHua,
Ho ChiTang
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400515
Subject(s) - epigenetics , breast cancer , carcinogenesis , cancer , cancer research , medicine , population , estrogen receptor , biology , bioinformatics , oncology , genetics , environmental health , gene
Breast cancer is a systemic malignant disease that is a major cause of cancer‐related death among women worldwide. Recently, multiple lines of evidence from epidemiologic studies have suggested that epigenetic and genetic changes are involved in breast cancer development. In breast cancer patients, hormone receptor status, breast cancer stem‐like cell population, and tumor microenvironment are reflective of breast cancer progression, drug resistance, and tumor recurrence. Strong relationships between a phytochemical‐rich diet and a reversal of epigenetic alterations and/or modulated signaling pathways of carcinogenesis (initiation, promotion, and progression) suggest a potential approach for preventing breast cancer. Additionally, dietary consumption of natural phenolic compounds containing phytoestrogen properties exerts beneficial effects in breast cancer chemoprevention. In this review, we summarize the specific chemopreventive targets of representative phenolic compounds with an emphasis on their efficacy at interfering with epigenetic event related hormonal and nonhormonal signaling cascades that are responsible for multistage breast carcinogenesis.