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Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini‐review
Author(s) -
Gan Nicholas P.,
Conn Carole A.,
Vaughan Roger A.
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400414
Subject(s) - glut4 , insulin resistance , hyperinsulinemia , endocrinology , medicine , glucose uptake , skeletal muscle , diabetes mellitus , chromosomal translocation , glucose transporter , adipose tissue , insulin , biology , biochemistry , gene
Chronic insulin resistance can lead to type II diabetes mellitus, which is also directly influenced by an individual's genetics as well as their lifestyle. Under normal circumstances, insulin facilitates glucose uptake in skeletal muscle and adipose tissue by stimulating glucose transporter 4 (GLUT4) translocation and activity. GLUT4 activity is directly correlated with the ability to clear elevated blood glucose and insulin sensitivity. In diabetes, energy excess and prolonged hyperinsulinemia suppress muscle and adipose response to insulin, in part through reduced GLUT4 membrane levels. This work uniquely describes much of the experimental data demonstrating the effects of various dietary components on GLUT4 expression and translocation in skeletal muscle. These observations implicate several individual dietary chemicals as potential adjuvant therapies in the maintenance of diabetes and insulin resistance.