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Effect of frying oils on the postprandial endoplasmic reticulum stress in obese people
Author(s) -
RangelZuñiga Oriol A.,
Haro Carmen,
PerezMartinez Pablo,
DelgadoLista Javier,
Marin Carmen,
QuintanaNavarro Gracia M.,
Tinahones Francisco J.,
Malagón María M.,
LopezSegura Fernando,
LópezMiranda Jose,
PerezJimenez Francisco,
Camargo Antonio
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400401
Subject(s) - postprandial , oxidative stress , sunflower oil , peripheral blood mononuclear cell , food science , unfolded protein response , endoplasmic reticulum , medicine , chemistry , endocrinology , biochemistry , insulin , in vitro
The addition of antioxidants to frying oil reduces postprandial oxidative stress and the inflammatory response. ER stress may trigger both inflammation and oxidative stress processes. We aimed to determine the biological effects of the intake of four models of frying oils on postprandial ER stress in peripheral blood mononuclear cells. Twenty obese people received four breakfasts following a randomized crossover design, consisting of muffins made with different oils (virgin olive oil (VOO), sunflower oil (SFO), and a mixture of seed oils (SFO/canola oil) with either dimethylpolysiloxane (SOD) or natural antioxidants from olives (SOP) added), which were previously subjected to 20 heating cycles. ER stress was assessed by measuring the mRNA levels of sXBP1 , BiP , CRT , and CNX in peripheral blood mononuclear cells. Our study showed that the intake of the muffins made with SFO induced the postprandial increase of the mRNA levels of the ER stress‐sensor sXBP1 , and the ER stress related chaperones BiP and CRT (all p ‐values <0.05). The harmful effects associated with the use of SFO as frying oil, in terms of inflammatory response and postprandial oxidative stress, may be partially mediated by the induction of postprandial ER stress.