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Red meat intake, insulin resistance, and markers of endothelial function among Iranian women
Author(s) -
Barak Farzaneh,
Falahi Ebrahim,
Keshteli Ammar Hassanzadeh,
Yazdannik Ahmadreza,
Saneei Parvane,
Esmaillzadeh Ahmad
Publication year - 2015
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201400333
Subject(s) - insulin resistance , red meat , insulin , medicine , confounding , glycemic index , endothelial dysfunction , homeostatic model assessment , food science , endocrinology , physiology , glycemic , biology , pathology
Scope Few data, with conflicting findings, are available linking red meat consumption to indicators of insulin resistance and endothelial dysfunction. This study aimed to investigate the association of red meat consumption with insulin resistance and endothelial dysfunction among a sample of female nurses in Isfahan, Iran. Methods and results This cross‐sectional study was carried out among 420 female nurses who were selected by a multistage cluster random sampling method. Usual dietary intakes were assessed using a validated food frequency questionnaire. Red meat intake was calculated by summing up the consumption of all kinds of red meat in foods and processed meat in sausages and fast foods. To measure serum concentrations of adhesion molecules and glycemic indexes, a fasting blood sample was taken. After adjustment for potential confounders, high red meat intake was significantly associated with higher fasting plasma glucose, homeostasis model assessment of insulin resistance, and lower quantitative insulin sensitivity check index. Although high red meat intake was significantly associated with higher serum insulin levels and lower homeostasis model assessment of beta‐cell function in the crude model, after controlling for BMI, the association was no longer significant. Red meat consumption was associated with high concentrations of E‐selectin, soluble vascular cell adhesion molecule‐1 (sVCAM‐1), and soluble intercellular adhesion molecule‐1 (sICAM‐1) after adjustment for different potential confounders. Conclusion We found that increased red meat intake was associated with high concentrations of plasma endothelial dysfunction biomarkers and abnormal glucose homeostasis among Iranian women. Prospective studies are required to confirm these findings.