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Moderate chronic administration of Vineatrol‐enriched red wines improves metabolic, oxidative, and inflammatory markers in hamsters fed a high‐fat diet
Author(s) -
Romain Cindy,
Bresciani Letizia,
Gaillet Sylvie,
FeilletCoudray Christine,
Calani Luca,
Bonafos Béatrice,
Vidé Joris,
Rugani Nathalie,
Ramos Jeanne,
Rio Daniele Del,
Cristol JeanPaul,
Rouanet JeanMax
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300853
Subject(s) - medicine , endocrinology , inflammation , steatosis , oxidative stress , ampk , nicotinamide adenine dinucleotide phosphate , biology , enzyme , oxidase test , biochemistry , protein kinase a
Scope High‐fat ( HF ) diets contribute to the development of cardiovascular diseases and the metabolic syndrome. This study was undertaken to investigate the beneficial effects of V ineatrol®‐enriched red wines on blood lipids, oxidative stress and inflammation, and the role of some metabolic pathway regulatory proteins. Methods and results Golden S yrian hamsters received an HF diet for 13 wk, in the presence or absence of red wines supplemented with V ineatrol® ( RWV ) or not. The HF diet increased plasma cholesterol, triglycerides, glucose, and insulin, which were attenuated by RWV treatment. RWV protected against the HF ‐induced increase in liver nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and spared antioxidant enzyme activities. RWV did not reduce either liver steatosis or increased plasma leptin due to the HF diet, but greatly improved adiponectinemia. In the liver, RWV affected the inflammatory response by decreasing polymorphonuclear cell number and lowering TNF ‐α and IL ‐6 levels. Moreover, the increase in NF ‐κB activity in the HF group liver was prevented by RWV . Finally, RWV partially corrected low SIRT 1 levels due to the HF diet but had no influence on SIRT 3 or p‐ AMPK protein levels. Conclusion Our studies suggest that RWV is capable of reversing the atherogenic process induced by an HF diet in hamster tissues.