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Dietary α‐mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice
Author(s) -
GutierrezOrozco Fabiola,
ThomasAhner Jennifer M.,
BermanBooty Lisa D.,
Galley Jeffrey D.,
Chitchumroonchokchai Chureeporn,
Mace Thomas,
Suksamrarn Sunit,
Bailey Michael T.,
Clinton Steven K.,
Lesinski Gregory B.,
Failla Mark L.
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300771
Subject(s) - xanthone , colitis , garcinia mangostana , dysbiosis , biology , medicine , gastroenterology , gut flora , immunology , traditional medicine , botany
Scope Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α‐Mangostin (α‐MG), the most abundant xanthone in mangosteen fruit, exerts anti‐inflammatory and antibacterial activities in vitro. We evaluated the impact of dietary α‐MG on murine experimental colitis and on the gut microbiota of healthy mice. Methods and results Colitis was induced in C57BL/6J mice by administration of dextran sulfate sodium (DSS). Mice were fed control diet or diet with α‐MG (0.1%). α‐MG exacerbated the pathology of DSS‐induced colitis. Mice fed diet with α‐MG had greater colonic inflammation and injury, as well as greater infiltration of CD3 + and F4/80 + cells, and colonic myeloperoxidase, than controls. Serum levels of granulocyte colony‐stimulating factor, IL‐6, and serum amyloid A were also greater in α‐MG‐fed animals than in controls. The colonic and cecal microbiota of healthy mice fed α‐MG but no DSS shifted to an increased abundance of Proteobacteria and decreased abundance of Firmicutes and Bacteroidetes, a profile similar to that found in human UC. Conclusion α‐MG exacerbated colonic pathology during DSS‐induced colitis. These effects may be associated with an induction of intestinal dysbiosis by α‐MG. Our results suggest that the use of α‐MG‐containing supplements by patients with UC may have unintentional risk.