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Molecular cross‐talk between members of distinct families of selenium containing proteins
Author(s) -
Ansong Emmanuel,
Yang Wancai,
Diamond Alan M.
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300543
Subject(s) - selenium , selenocysteine , disease , biology , cancer , biochemistry , enzyme , function (biology) , genetics , chemistry , medicine , organic chemistry , cysteine
Dietary intake of selenium has been associated with reduced risk of several cancer types, and this is likely due to its role as a specific constituent of selenium containing proteins. One of these, selenium‐binding protein 1 ( SBP 1), is a protein of unknown function that has been shown to be reduced in tumors of diverse tissue types as compared to the corresponding normal tissue. More importantly, SBP 1 has also been reported to be a predictor of clinical outcome. Levels of SBP 1 are inversely associated with the levels of another protein representative of a different class of selenoproteins, glutathione peroxidase1 ( GP x‐1). GP x‐1 is an anti‐oxidant, selenocysteine containing enzyme implicated in several diseases, including cancer, due to the association of specific alleles with disease risk. The relationship between SBP 1 and GP x‐1 represents a unique example of a molecular interaction between selenium containing proteins with a likely significant impact on human health and disease.