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Prediction of the wine polyphenol metabolic space: An application of the P henol‐ E xplorer database
Author(s) -
BotoOrdóñez María,
Rothwell Joseph A.,
AndresLacueva Cristina,
Manach Claudine,
Scalbert Augustin,
UrpiSarda Mireia
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300411
Subject(s) - wine , polyphenol , chemistry , food science , biochemistry , database , computer science , antioxidant
Scope Knowledge of in vivo polyphenol metabolites derived from the consumption of red wine could be key to understanding its health benefits. This work aimed to predict the wine polyphenol metabolic space in biofluids by using all available data compiled in the Phenol‐Explorer database. Methods and results A search strategy was developed for Phenol‐Explorer to obtain the widest range of metabolites related to wine consumption. A total of 97 metabolites have been described in intervention studies with wine and related products ( n = 37), and after consumption of pure compounds known to be wine constituents ( n = 90). These 97 metabolites, derived from host and microbial metabolism of several classes of polyphenols, were found in plasma and urine samples and some of them have demonstrated higher or lower biological activities than the parent compound in in vitro studies. The metabolites have been linked to generate, for the first time, a global pathway map of wine in vivo polyphenol metabolism. Conclusion The retrieval of the widest range of metabolites so far described and their assembly as a metabolic pathway map could aid the identification of possible biomarkers of wine consumption and improve current understanding of the health effects of wine consumption.