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Plant polyphenols in the treatment of age‐associated diseases: Revealing the pleiotropic effects of icariin by network analysis
Author(s) -
Schluesener Jan Kevin,
Schluesener Hermann
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300409
Subject(s) - icariin , polyphenol , sirtuin , neurodegeneration , pharmacology , diabetes mellitus , mapk/erk pathway , inflammation , medicine , bioinformatics , biology , computational biology , signal transduction , disease , biochemistry , endocrinology , antioxidant , alternative medicine , pathology , gene , acetylation
Polyphenols are a broad class of compounds. Some are ingested in substantial quantities from nutritional sources, more are produced by medicinal plants, and some of them are taken as drugs. It is becoming clear, that a single polyphenol is impacting several cellular pathways. Thus, a network approach is becoming feasible, describing the interaction of a single polyphenol with cellular networks. Here we have selected icariin to draw a prototypic network of icariin activities. Icariin appears to be a promising drug to treat major age‐related diseases, like neurodegeneration, memory and depressive disorders, chronic inflammation, diabetes, and osteoporosis. It interacts with several relevant pathways, like PDE , TGF‐ß , MAPK , PPAR , NOS , IGF , Sirtuin , and others. Such networks will be useful to future comparative studies of complex effects of polyphenols.