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REV ‐ ERB ‐ ALPHA circadian gene variant associates with obesity in two independent populations: M editerranean and N orth A merican
Author(s) -
Garaulet Marta,
Smith Caren E.,
GomezAbellán Purificación,
OrdovásMontañés María,
Lee YuChi,
Parnell Laurence D.,
Arnett Donna K.,
Ordovás José M.
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300361
Subject(s) - obesity , genotype , biology , allele , locus (genetics) , population , endocrinology , circadian rhythm , genetics , alpha (finance) , medicine , gene , environmental health , construct validity , nursing , patient satisfaction
Scope Despite the solid connection between REV ‐ ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV ‐ ERB ‐ ALPHA 1 rs2314339 and obesity in two independent populations. Methods and results Participants were 2214 subjects from S panish M editerranean ( n = 1404) and N orth A merican ( n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV ‐ ERB ‐ ALPHA 1 rs2314339 genotype and obesity in two independent populations: in S panish M editerranean and N orth A merican groups, the frequency of the minor‐allele‐carriers ( AA + AG ) was significantly lower in the “abdominally obese” group than in those of the “nonabdominally obese” group ( p < 0.05). Minor allele carriers had lower probability of abdominal obesity than noncarriers, and the effect was of similar magnitude for both populations ( OR ≈ 1.50). There were consistent associations between REV ‐ ERB ‐ ALPHA 1 genotype and obesity‐related traits ( p < 0.05). Energy intake was not significantly associated with REV ‐ ERB ‐ ALPHA 1 rs2314339. However, physical activity significantly differed by genotype. A significant interaction between the REV ‐ ERB ‐ ALPHA 1 variant and monounsaturated‐fatty‐acids ( MUFA ) intake for obesity was also detected in the M editerranean population. Conclusion This new discovery highlights the importance of REV ‐ ERB ‐ ALPHA 1 in obesity and provides evidence for the connection between our biological clock and obesity‐related traits.