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Probiotics determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters
Author(s) -
Stancu Camelia Sorina,
Sanda Gabriela Maria,
Deleanu Mariana,
Sima Anca Volumnia
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300224
Subject(s) - microsomal triglyceride transfer protein , hyperlipidemia , medicine , endocrinology , antioxidant , paraoxonase , oxidative stress , chemistry , cholesterol , biochemistry , lipoprotein , diabetes mellitus , very low density lipoprotein
Scope Hyperlipidemia, hyperglycemia, and the oxidative stress are among the known risk factors of atherosclerosis. Our aim was to assess the hypolipidemic and antioxidant effects of a probiotic mix ( L actobacillus acidophilus and B ifidobacterium animalis) in hyperlipidemic hamsters ( HL ). Methods and results Male G olden S yrian hamsters developed hyperlipidemia after 21 weeks of fat diet. For the last 5 weeks of experiment, ten HL were treated with the probiotic mix ( HLP ), ten received water ( HL ). Ten animals received standard chow ( N ). Increase of plasma total cholesterol ( TC ), triglycerides ( TG ), phospholipids ( PL ), oxidized LDL , glucose, of 4‐hydroxynonenal (4‐ HNE ) in plasma, liver, and myocardium, and of intestinal N iemann P ick C 1 like 1 ( NPC 1 L 1) and microsomal TG transfer protein ( MTTP ) expression was observed in HL versus N . The probiotic mix decreased plasma TC , TG , PL , oxidized LDL , 4‐ HNE , and glucose levels and increased paraoxonase‐1 activity, decreased NPC 1 L 1 and MTTP protein expression compared to HL . In HLP liver, a significant reduction of TC , TG , and fatty acids was observed. PL increased and 4‐ HNE levels decreased in the liver and myocardium of HLP versus HL . Conclusion Our data support the administration of probiotics to humans because of their hypolipidemic (through decreasing intestinal NPC 1 L 1 and MTTP ) and antioxidant effects (stimulating HDL ‐associated paraoxonase‐1).