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Polymorphisms in the SCD 1 gene are associated with indices of stearoyl C o A desaturase activity and obesity: A prospective study
Author(s) -
MartínNúñez Gracia María,
CabreraMulero Rebeca,
RojoMartínez Gemma,
GómezZumaquero Juan Miguel,
Chaves Felipe Javier,
de Marco Griselda,
Soriguer Federico,
Castaño Luis,
Morcillo Sonsoles
Publication year - 2013
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300208
Subject(s) - stearoyl coa desaturase , gene , chemistry , food science , gene expression , biochemistry
Scope The serum fatty acid ( FA ) composition is influenced by dietary fat and the endogenous production of FA s. Stearoyl C o A desaturase 1 ( SCD 1) is the rate‐limiting enzyme catalyzing the synthesis of MUFA s from saturated FA s. Variations in SCD 1 activity have been associated with obesity, diabetes, or inflammation. We evaluated the associations between genetic variation of the SCD 1 gene, SCD 1 activity, intake of oil, and obesity in a population‐based prospective study in southern S pain. Methods and results We collected phenotypic, metabolic, nutritional, and genetic information. The type of dietary fat was assessed from samples of cooking oil taken from the participants’ kitchens and analyzed by GC . A total of nine single nucleotide polymorphisms (SNPs) of the SCD 1 gene were analyzed by SNP lex technology. We found a significant association between SCD 1 genetic variation and enzyme activity in four of nine polymorphisms studied. An interaction between rs10883463 and olive oil intake on the [18:1/18:0] desaturase index was found ( p = 0.009). We also showed that genetic variations in the SCD 1 gene were associated with obesity. Conclusion Our results show a relationship between genetic variation of the SCD 1 gene, enzyme activity, and the risk of obesity, an association that is not independent of the type of oil consumed.