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Favorable effect of moderate dose caffeine on the skeletal system in ovariectomized rats
Author(s) -
Folwarczna Joanna,
Pytlik Maria,
Zych Maria,
Cegieła Urszula,
KaczmarczykSedlak Ilona,
Nowińska Barbara,
Śliwiński Leszek
Publication year - 2013
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201300123
Subject(s) - ovariectomized rat , caffeine , endocrinology , medicine , osteoporosis , cancellous bone , estrogen , bone remodeling , calcium , bone density , chemistry , surgery
Scope Caffeine, a methylxanthine present in coffee, has been postulated to be responsible for an increased risk of osteoporosis in coffee drinkers; however, the data are inconsistent. The aim of the present study was to investigate the effects of a moderate dose of caffeine on the skeletal system of rats with normal and decreased estrogen level (developing osteoporosis due to estrogen deficiency). Methods and results The experiments were carried out on mature nonovariectomized and ovariectomized W istar rats, divided into control rats and rats receiving caffeine once daily, 20 mg/kg p.o., for 4 wk. Serum bone turnover markers, bone mass, mass of bone mineral, calcium and phosphorus content, histomorphometric parameters, and bone mechanical properties were examined. Caffeine favorably affected the skeletal system of ovariectomized rats, slightly inhibiting the development of bone changes induced by estrogen deficiency (increasing bone mineralization, and improving the strength and structure of cancellous bone). Moreover, it favorably affected mechanical properties of compact bone. There were no significant effects of caffeine in rats with normal estrogen levels. Conclusion In conclusion, results of the present study indicate that low‐to‐moderate caffeine intake may exert some beneficial effects on the skeletal system of mature organisms.