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Exposure of breastfed infants to quercetin after consumption of a single meal rich in quercetin by their mothers
Author(s) -
Romaszko Ewa,
Wiczkowski Wiesław,
Romaszko Jerzy,
Honke Joanna,
Piskula Mariusz K.
Publication year - 2014
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201200773
Subject(s) - quercetin , meal , breastfeeding , breast milk , zoology , medicine , urine , breast feeding , antioxidant , food science , chemistry , endocrinology , biology , pediatrics , biochemistry
Scope The exposure to quercetin ( Q ) has not been studied in breastfed infants whose mothers were consuming a Q ‐rich diet. The objective of the study was to determine whether plant‐origin antioxidant‐ Q passes from the mother's diet to her milk and to calculate the pharmacokinetic parameters of this phenomenon. Methods and results Eleven breastfeeding women were included in this controlled case study. Volunteers followed a Q ‐restricted diet for 5 consecutive days with the exception of the 3rd day when they received a single meal providing 1 mg of Q per kg of body weight. Urine analysis showed the presence of Q already in the first collected samples after the test (1.5–4 h), which indicated its rapid absorption from the meal. The C max = 68 ± 8.44 nmol/L concentration of Q in the milk was calculated for T max = 11.89 ± 3.37 h. It was significantly different ( p = 0.007) from 40 nmol/L and ( p = 0.016) from 42 nmol/L of Q concentration before and 48 h after the test, respectively. Conclusions Q was shown to be a component of human milk at the nmol/L level. Infants breastfed by mothers consuming a diet rich in Q are exposed to a dose of approximately 0.01 mg of Q daily.