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Modulation of lipid metabolism by polyphenol‐rich grape skin extract improves liver steatosis and adiposity in high fat fed mice
Author(s) -
Park HaeJin,
Jung Un Ju,
Lee MiKyung,
Cho SuJung,
Jung HeeKyoung,
Hong Joo Heon,
Park Yong Bok,
Kim Sang Ryong,
Shim Sangphil,
Jung Jieun,
Choi MyungSook
Publication year - 2013
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201200447
Subject(s) - lipogenesis , steatosis , endocrinology , medicine , adipose tissue , adiponectin , lipid metabolism , fatty acid synthase , lipolysis , chemistry , beta oxidation , leptin , fatty liver , lipid oxidation , metabolism , biology , biochemistry , obesity , insulin resistance , antioxidant , disease
This study investigated the influence of polyphenol‐rich grape skin extract ( GSE ) on adiposity and hepatic steatosis in mice fed a high fat diet ( HFD ) and its underlying mechanisms based on adipose and hepatic lipid metabolism. C57BL/6J mice were fed a normal diet or a HFD (20% fat, w/w) with or without GSE (0.15%, w/w) for 10 weeks. The supplementation of GSE significantly lowered body weight, fat weight, plasma free fatty acid level, and hepatic lipid accumulation compared to the HFD group. Plasma leptin level was significantly lower, while the plasma adiponectin level was higher in the GSE group than in the HFD group. GSE supplementation significantly suppressed the activities of lipogenic enzymes in both adipose and liver tissues, which was concomitant with β‐oxidation activation. Furthermore, GSE reversed the HFD ‐induced changes of the expression of genes involved in lipogenesis and β‐oxidation in the liver. These findings suggest that GSE may protect against diet‐induced adiposity and hepatic steatosis by regulating m RNA expression and/or activities of enzymes that regulate lipogenesis and fatty acid oxidation in the adipose tissue and liver.