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The impact of the catechol‐ O ‐methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion
Author(s) -
Miller Rosalind J.,
Jackson Kim G.,
Dadd Tony,
Mayes Andrew E.,
Brown A. Louise,
Lovegrove Julie A.,
Minihane Anne M.
Publication year - 2012
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201100726
Subject(s) - ingestion , catechol o methyl transferase , blood pressure , genotype , chemistry , catechol , function (biology) , pharmacology , medicine , food science , biology , biochemistry , gene , genetics
Scope Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol‐ O ‐methyltransferase ( COMT ) genotype on vascular function and blood pressure ( BP ) after green tea extract ingestion are reported. Methods and results Fifty subjects ( n = 25 of the proposed low‐activity [ AA ] and of the high‐activity [ GG ] COMT rs4680 genotype), completed a randomized, double‐blind, crossover study. Peripheral arterial tonometry, digital volume pulse ( DVP ), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index ( p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo ( p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration ( p = 0.049). Conclusion Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.