Premium
Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: A randomized, double‐blind, placebo‐controlled trial
Author(s) -
Cui Xiangli,
Jin Yu,
Singh Udai P.,
Chumanevich Alexander A.,
Harmon Brook,
Cavicchia Philip,
Hofseth Anne B.,
Kotakadi Venkata,
Poudyal Deepak,
Stroud Brandy,
Volate Suresh R,
Hurley Thomas G.,
Hebert James R.,
Hofseth Lorne J.
Publication year - 2012
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201100496
Subject(s) - placebo , dna damage , inflammation , medicine , capsule , peripheral blood , double blind , whole blood , food science , dna , double blind study , pharmacology , immunology , chemistry , biology , pathology , biochemistry , botany , alternative medicine
Chronic inflammation contributes to many prevalent diseases worldwide, and it is widely accepted that inflammatory molecules contribute to DNA damage. In this ancillary study, we investigated the influence of an encapsulated fruit and vegetable juice powder concentrate on peripheral blood lymphocytes (PBL) DNA damage. Using a double‐blind, placebo‐controlled approach, subjects were randomly assigned capsules containing placebo, or one of two formulations of the juice powder. Blood was drawn at baseline and after 60 days of capsule consumption. We found DNA damage in isolated PBL is suppressed after consumption of the encapsulated juice powder, and damage was correlated with the level of systemic inflammation. These data suggest a potential health benefit by consuming the juice concentrate capsules through their ability to suppress DNA damage as measured in surrogate tissues (PBL).