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Diet high in oat β‐glucan activates the gut‐hypothalamic (PYY 3–36 ‐NPY) axis and increases satiety in diet‐induced obesity in mice
Author(s) -
Huang XuFeng,
Yu Yinghua,
Beck Eleanor J.,
South Tim,
Li Yulin,
Batterham Marijka J.,
Tapsell Linda C.,
Chen Jiezhong
Publication year - 2011
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201100095
Subject(s) - neuropeptide y receptor , endocrinology , peptide yy , medicine , arc (geometry) , hypothalamus , chemistry , appetite , obesity , neuropeptide , biology , receptor , geometry , mathematics
This study tested the effects of (1→3),(1→4) β‐ D ‐glucan from oats, on activation of the gut‐hypothalamic (PYY 3–36 ‐NPY) axis, satiety, and weight loss in diet‐induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of β‐glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y‐Y 3‐36 (PYY 3‐36 ) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (‐13%, p<0.05) and body weight gain was lower with increasing β‐glucan over 6 wk with acute suppression of energy intake over 4 h. The highest β‐glucan diet significantly increased plasma PYY 3‐36 , with suppression of Arc NPY mRNA.